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The lack of an ISR and WO-ISA in respect of those parts of the international application for which no additional search fee was paid does not, of itself, have any influence on the validity of the international application. However, the national law of any designated Office may provide that the non-searched parts are considered withdrawn unless a special fee is paid. For further information see the national chapter for the designated Office concerned in the WIPO PCT Guide.
WIPO PCT Guide 7.021
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the EPO as IPEA will not perform the international preliminary examination in respect of any claims relating to an invention for which no additional search fee was paid and, therefore, for which no ISR was established (see point 382)
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upon entry into the European phase the EPO as designated Office will consider whether the application, which in the meantime may have been amended by the applicant, meets the requirement of unity of invention. If not, the examining division will invite the applicant to restrict the application to one single invention. Where not all inventions contained in the application were searched by the EPO because of non-payment of an additional search fee, the applicant must restrict the application to one of the inventions covered by the ISR (or the SISR, see point 293). Since an unsearched invention may only be pursued in the European phase by filing a divisional application a decision on non-payment of additional search fees in the international phase is to be well considered (see point 635).
GL/EPO E-VIII, 2.4.1