Nucleotide and amino acid sequences 
If your European patent application discloses nucleotide or amino acid sequences, the description must include a sequence listing in electronic format complying with WIPO Standard ST.25 or, for European patent applications having a filing date on or after 1 July 2022, WIPO Standard ST.26. You are advised to use the EPO's free BiSSAP or PatentIn software (for sequence listings in Standard ST.25) or WIPO's free "WIPO Sequence" software (for sequence listings in Standard ST.26), which simplify the creation of ST.25 TXT or ST.26 XML sequence listings. The sequence listing must not be filed on paper or in PDF format or, for applications filed on or after 1 July 2022, in TXT format. 
Electronic sequence listings are usually filed online, using one of the EPO's online filing tools. Uploading to EPO Form 1001 is enabled if you indicate that the application includes a sequence listing by ticking the relevant check box ("Biology/Application details" tab). Further advice is obtainable from the EPO by contacting User Services at
The standardised presentation of such nucleotide and amino acid sequences in electronic form is mandatory. If you do not comply with the requirements even following an invitation to do so, including payment of the late furnishing fee, your European patent application will be refused (but see point 5.10.007).

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