Sequence submission tools


Information for users of BiSSAP  (version 1.3 or earlier)

The problems reported for older versions of BiSSAP have been resolved in new BiSSAP version 1.3.6, currently available only for Windows users. Mac OS and Linux versions will not be updated to be compatible with Java 8.

About BiSSAP

BiSSAP is a computer program designed to facilitate the creation of sequence listings for patent applications containing biological sequences (see Rule 30 EPC, Rule 5.2 PCT, the Decision of the President dated 28 April 2011 (OJ EPO 6/2011, 372) and the Notice from the EPO dated 18 October 2013 (OJ EPO 11/2013, 542)).

It has been developed by the European Patent Office in collaboration with national patent offices and the European Bioinformatics Institute.

BiSSAP can be used to prepare and verify sequences, generate the sequence listing files for submission, import existing sequence listings in WIPO ST.25 and convert between sequence listing formats (WIPO ST.25 and XML proposal). It also contains a "batch verification" module allowing users to verify collections of sequence listings.

Patent sequence data:

You can access published patent sequence data and other published patent data resources in life sciences via the EBI's website.

System requirements BiSSAP 1.3.6:

BiSSAP will run on the following operating systems:

  • Windows Vista and Windows 7, 8, 8.1 or 10 (both 32- and 64-bit systems).

Your workstation must also meet the following technical requirements:

  • 2 GB RAM (4 GB recommended)
  • 4 GB free hard-disk space for program files and data (the necessary disk space depends on the total data volume of your sequence listing projects)
  • Screen resolution 1 280 x 900 pixels (greater than 1 680 x 1 200 recommended)
  • Java 8 JRE (build 1.8 or newer) installed

This version is backward compatible with:

  • Windows Vista and Windows 7 and 8 (64-bit systems); Java 6 and 7

System requirements BiSSAP 1.3:

BiSSAP will run on the following operating systems:

  • Mac OS X (10.5.5 or higher, 10.6.1 or higher)
  • Linux (with GTK libraries)

Your workstation must also meet the following technical requirements:

  • 1 GB RAM (recommended: 2 GB)
  • 100 MB disk space for installation, with additional disk space for data
  • Screen resolution 1 280 x 900 (recommended: 1 680 x 1 200 or higher)
  • Java 6 JRE installed

BiSSAP is a desktop application which does not require an internet connection.  However, taxonomies and certain help pages are updated automatically if the workstation is connected to the internet.

Please contact us with any questions you may have.


PatentIn is a computer program designed to help you prepare patent applications containing nucleic acid and amino acid sequences. For details and downloads, visit the USPTO website.

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